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Listar por autor "Smani Hajami, Tarik"
Mostrando ítems 1-20 de 40
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Artículo
Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells
Smani Hajami, Tarik; Falcón Boyano, Débora (2019-10-23)Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel ...
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Tesis Doctoral
Caracterización del papel de las poblaciones inflamatorias en el infarto revascularizado y sus implicaciones en el remodelado adverso
Bevilacqua, Elisa (2023-07-13)La revascularización temprana después del infarto permite reestablecer el flujo sanguíneo a la zona infartada del corazón ...
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Artículo
Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation
Mayoral-González, Isabel; Calderón Sánchez, Eva M.; Galeano-Otero, Isabel; Martín Bórnez, Marta; Gutiérrez Carretero, Encarnación; Fernández Velasco, María; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (CELL PRESS (Elsevier), 2022)Urocortin-2 (Ucn-2) has demonstrated cardioprotective ac tions against myocardial ischemia-reperfusion (I/R) injuries. Herein, ...
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Tesis Doctoral
Comunicación funcional entre canales de Ca2+ tipo l y canales de Ca2+ activados por reservorios y su regulación del tono vascular
Ávila Medina, Javier (2017-07-07) -
Artículo
Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19
Hmadcha, Abdelkrim; Soria, Bernat; Zhao, Robert C.; Smani Hajami, Tarik; Valverde Pérez, Israel (Frontiers Media, 2021-12-14)We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of ...
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Artículo
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
Braidy, Nady; Smani Hajami, Tarik; Naziroglu, Mustafa (Fontiers Media SA, 2021)The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and ...
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Artículo
Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
Gruszczynska-Biegala, Joanna; Martín-Romero, Francisco Javier; Smani Hajami, Tarik; Secondo, Agnese (Frontiers Media, 2021-10-05)Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This ...
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Artículo
EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
Albarran, Letizia; Lopez, Jose J.; Jardin, Isaac; Sanchez-Collado, Jose; Berna-Erro, Alejandro; Smani Hajami, Tarik; Rosado, Juan Antonio (S. Karger AG, 2018-11-28)Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved ...
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Tesis Doctoral
Estudio molecular de la cardioprotección inducida por Urocortina frente al síndrome de isquemia/repercusión.
Díaz Carrasco, Ignacio (2016-06-08)Las enfermedades cardiovasculares siguen siendo la principal causa de morbimortalidad en los países desarrollados (Figura ...
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Tesis Doctoral
Evaluación de la imagen multimodal para la impresión 3D en cardiopatías congénitas: docencia, aplicaciones clínicas y perspectivas futuras
Valverde Pérez, Israel (2022-12-15)Las cardiopatías congénitas son las malformaciones presentes al nacimiento más frecuentes, y tienen un impacto muy ...
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Artículo
Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells
López, Jose J.; Siegfried, Geraldine; Cantonero, Carlos; Soulet, Fabienne; Descarpentrie, Jean; Smani Hajami, Tarik (MDPI, 2021-04-01)Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturation ...
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Tesis Doctoral
Homeostasis del calcio en miocitos del árbol arterial pulmonar
Smani Hajami, Tarik (2000-07-24)En el presente trabajo se ha estudiado la homeostasis de la (Ca2+) i en miocitos aislados de la arteria pulmonar y el ...
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Tesis Doctoral
Implicación de la entrada de calcio regulada por los reservorios en la vasoconstricción y proliferación inducida por urotensina-ii en aorta
Rodríguez Moyano, María (2012-06-26)En los últimos años, la terminación de la primera parte del Proyecto Genoma Humano ha traído consigo la identificación de ...
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Artículo
Innate Immune Receptors, Key Actors in Cardiovascular Diseases
Jaén, Rafael I.; Val-Blasco, Almudena; Prieto, Patricia; Gil-Fernández, Marta; Smani Hajami, Tarik; López-Sendón, José Luis (Elsevier on behalf of the American College of Cardiology Foundation, 2020)Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with ...
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Artículo
Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells
Jardín, Isaac; Díez-Bello, Raquel; Falcón Boyano, Débora; Alvarado, Sandra; Regodón, Sergio; Salido, Gines M.; Smani Hajami, Tarik; Rosado, Juan A. (Amer Soc Biochemistry Molecular Biology Inc, 2021)Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including ...
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Artículo
miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemiareperfusion injury
Díaz, Ignacio; Calderón Sánchez, Eva María; Toro Estévez, Raquel del; Ávila Medina, Javier; Sánchez de Rojas de Pedro, Eva; Domínguez Rodríguez, Alejandro; Ordóñez Fernández, Antonio; Smani Hajami, Tarik (Nature Research, 2017)Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemiareperfusion (I/R) ...
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Artículo
miR-30b-5p Downregulation as a predictive biomarker of coronary in-stent restenosis
Gutiérrez Carretero, Encarnación; Mayoral González, Isabel; Morón, Francisco Jesús; Fernandez-Quero, Mónica; Domínguez Rodríguez, Alejandro; Ordoñez, Antonio; Smani Hajami, Tarik (2021-03-30)In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting ...
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Artículo
miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
López Beas, Javier; Capilla González, Vivian; Aguilera, Yolanda; Mellado, Nuria; Lachaud, Christian; Martín, Franz; Smani Hajami, Tarik; Soria Escoms, Bernat; Hmadcha, Abdelkrim (The American Society of Gene and Cell Therapy, 2018-09-07)Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this ...
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Artículo
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
Ávila Medina, Javier; Calderón Sánchez, Eva María; González-Rodríguez, Patricia; Monje Quiroga, Francisco; Rosado, Juan Antonio; Castellano Orozco, Antonio Gonzalo; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (American Society for Biochemistry and Molecular Biology, 2016)Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle ...
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Artículo
Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
Sánchez Collado, José; López, José J.; Jardín, Isaac; Berna-Erro, Alejandro; Camello, Pedro J.; Cantonero, Carlos; Smani Hajami, Tarik; Salido, Gines M.; Rosado, Juan A. (Springer, 2022)The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel ...